青春期不同月经方式的多囊卵巢综合征120例育龄期内分泌状态的研究

120 PCOS with different pattern of menstrual cycle in puberty

目的 探讨青春期不同月经方式的多囊卵巢综合征 (PCOS)患者在育龄期内分泌状态。方法 选择12 0例PCOS育龄妇女 ,按青春期月经方式分为三组。测定其血清性激素、胰岛素、血糖 ,并进行分析对比。结果 原发不孕的PCOS患者青春期月经异常的发生率明显高于继发不孕的PCOS患者 (P <0 0 5 )。青春期月经稀发组T及E2 显著高于继发闭经组 ,A显著高于月经规律组 (P <0 0 5 )。继发闭经组胰岛素拮抗指数和BMI显著高于月经规律组 (P <0 0 5 )。结论 在青春期表现有月经稀发和继发闭经的PCOS患者在育龄期有更严重的分泌代谢失调、并伴有较低的妊娠率。

Objective To investigate the relationship between different menstrual cycle pattern in puberty and endocrinal condition in reproductive period in patients with polycystic ovary syndrome.Methods 120 patients in reproductive period with PCOS were divided into three groups according to the menstrual cycle pattern in puberty and were studied by radioimmunoassays for serum sextual hormone,insulin and blood glucose level.Results PCOS patients with primary infertility showed more obvious abnormal menstruation in puberty than those with secondary infertility(P<0.05).T and E 2 levels were significantly higher in oligomenorrhea group than those in secondary amenorrhea group,while A significantly higher than that in regular menstruation group(P<0.05).In addition,between the groups of secondary amenorrhea and regular menstruation,insulin resistant index and body mass index were significantly higher in the former (P<0.05).Conclusion The reproductive patients with PCOS who had oligomenorrhea and secondary amenorrhoea in puberty have more severe endocrinal disorders,such as hyperandrogenism and insulin resistant with lower fertility.