双波长分光光度法测定复方盐酸麻黄碱滴鼻液含量

Determination of Element Content in Compound Ephedrine Hydrochloride Nasal Drops by Dual-wavelength Spectrophotometry

目的 :测定复方盐酸麻黄碱滴鼻液中盐酸麻黄碱和盐酸苯海拉明含量。方法 :采用双波长紫外分光光度法测定 ,水作溶剂 ,选择盐酸麻黄碱和盐酸苯海拉明的测定波长对分别为 2 5 7.0nm 2 3 9.4nm和 2 3 0 .0nm 2 69.6nm。结果 :盐酸麻黄碱和盐酸苯海拉明的平均回收率分别为 99.95 %和 99.3 7%,RSD分别为 1.0 4%和 0 .67%。结论 :该方法可用于复方盐酸麻黄碱滴鼻液的质量控制 。

Objective:To establish a method for determining the contents of ephedrine hydrochlorde and diphenydramine hydrochloride in nasal drops. Methods:A dual wavelength spectrophotometry was used to determine the element contents of compound ephedrine hydrochloride nasal drops. The wavelength sets of ephedrine hydrochloride and diphenydramine hydrochloride were at 257.0 nm/239.4 nm and 230.0 nm/269 nm, respectively. Results:The respective average recovery of ephedrine hydrochloride and diphenydramine hydrochloride were 99.95% and the RSD of them were 1.04% and 0.67%( n =5). Conclusion:The method we used was simple for hospital pharmacy.