内镜活检食管癌组织E-CD蛋白的检测及其意义

Detection of Adhesion Melecule E-CD in Esophageal Squamous Cell Carcinoma Patients Undergoing Esophagoscopy and it's Significance

目的 探讨内镜活检组织E -CD检测对食管癌浸润转移的诊断价值。方法 采用免疫组织化学LSAB技术检测食管癌活检组织和对照组中E -CD的表达 ,分析其表达与癌侵袭转移的关系。结果E -CD蛋白表达与食管癌患者年龄、性别、发生部位无关 (P >0 .0 5) ;与食管癌细胞分化程度相关 (P <0 .0 5) ,与食管癌浸润深度、淋巴结转移密切相关 (P <0 .0 1 )。结论 E -CD与肿瘤侵袭转移相关 ,食管癌活检组织中E -CD蛋白表达可以作为预测癌浸润转移潜能标志之一。

Objective To study the expression of E-CD and its clinical significance in esophaged squanous cell carcinoma patients undergoing esophagoscopy. Methods E-CD expressions were determined in undergiong esophagoscopy tissues from 63 esophageal squamous cell carcinoma and in normal esophageal tissues with immunohistochemical LSAB methods. Results Expression of E-CD was not related to age, sex, location in esophageal squamous cell carcinoma patients ( P >0.05); The correlation was observed between low E-CD expression and cellular differentiation of esophageal squmous cell carcinoma ( P <0.05); The significant correlation was found between E-CD expression and its invasion, metastasis ( P <0.01). Conclusion Low E-CD expression was related to invasion and metastasis in esophageal squamous cell carcinoma patients undergoing esophagoscopy, and can be regarded as an imporptant sign of invation and metastasis.