马兜铃属中药所致大鼠急性中毒性间质性肾炎的研究

Study on Acute Interstitial Nephritis Damaged by Aristolochia Chinese Medicine in Rats

目的 观察马兜铃属中药所致急性肾损伤时肾功能变化及组织形态学特点。方法 用马兜铃属中药水煎剂 [60g/ (kg.·d) ]按时间不同分 3组 (3、7、1 5d)给大白鼠灌胃 ,建立急性肾损伤动物模型 ,并与正常组和生理盐水组肾功能对照 ,检测有关肾功能指标 ,进行组织学观察。结果 马兜铃属大白鼠肾功能改变为 :氮质血症、低渗尿、蛋白尿、糖尿、血尿。组织形态学改变主要表现为急性肾小管坏死 ,肾小球出血、肾间质出血以及纤维化。结论 马兜铃属中药水煎剂可导致大鼠急性肾功能损伤。并发现其电解质紊乱的规律 ,提示临床注意。另一方面发现肾小球和肾皮质出血的病理变化等 ,对其机理进行了探讨 。

Object Watch the change of kidney-function and character of tectology, when the kidney is damaged acutely by Aristolochia Chinese medicine. Method Set up the animal model being in acute kidney damage by affusing the water-fried Aristolochia Chinese medicine to the rid which were divided into three groups according to the affusing time(3 days,7 days,15 days). Watch the change of structure in the meantime. Result The main change of kidney-function resulted by Aristolochia Chinese medicine is azotemia, hyposthenuria,protenuria,hematuria,glucosuria, while change of the tectology is renal tubular necrosis,glomerulus hemorrhage, renal interstitial hemorrhage and fibrosis. Conclusion Water-fried Aristolochia Chinese medicine can bring the rat the acute kidney damage and the inordinate electrolyte,which should be paid attention to in clinic.we also found out the pathologic change of the bleeding glomerulus and renal cortex,which can provide basis for the further research.