亚低温治疗对急性重型颅脑损伤患者免疫功能的影响

EFFECT OF MILD HYPOTHERMIA ON IMMUNOCOMPETENCE OF SEVERE BRAIN INJURY

目的 :研究亚低温治疗对急性重型颅脑损伤患者免疫功能及预后的影响。方法 :对 98例急性重型颅脑损伤者按数字随机法分为亚低温组 5 0例、对照组 4 8例。亚低温组接受亚低温和常规治疗 ,对照组仅作常规治疗 ,两组病例均测定血清淋巴细胞转化率 (L TT)、C-反应蛋白 (CRP)、免疫球蛋白 Ig G、Ig A、Ig M等指标并观察呼吸道感染和预后。结果 :亚低温组的 L TT、CRP、Ig A、Ig G、Ig M、等指标多数正常 ,对照组的 CRP、病死率均明显升高 (P <0 .0 5 )。结论 :亚低温对急性重型颅脑损伤患者的免疫功能有明显的稳定和保护作用 。

Objective: To study the effects of mild hypothermia on the patients with severe brain injury and prognosis Methods: All 98 patients with severe brain injury (Glasgow coma scale score of 8 or less on admission) were randomly divided into the hypothermic group (50 cases) and control group(48 cases) The treatment of hypothermia was mild hypothermia combination with conventional therapy and the control group was treated conventionally, In each group The serumal lymphocyte transfomation rate (LTT), creactive protein(CRP), immunoglobuliu G, A, M (IgG, IgA, IgM), and prognosis were determined and difference between them was analyzed by chi square test Results: In hypothermic group, the mass of parameters were normal but tht level of CRP and mortality in control group was increased significantly (P<0 05)  Comclusions:Mild hypothermia therapy has tranquilization effect and safe immunity function, that also improve prognosis observably of the severe brain injury