阿尔茨海默病患者血清中巨噬细胞集落刺激因子

Serum Levels of Macrophage Colony Stimulating Factor in the Patients with Alzheimer's Disease

目的寻找阿尔茨海默病(Alzheimersdisease,AD)患者早期诊断和监视病情动态变化的血清检测指标。方法检测70例AD患者、52例年龄匹配的健康人(对照组)和22例血管性痴呆(VAD)对照患者血清中巨噬细胞集落刺激因子(M-CSF)的水平,以及32例AD患者和20例年龄匹配的健康人(对照组)血清中IL-1β、IL-6、肿瘤坏死因子-α(TNF-α)水平,并结合AD患者的病情进行分析对比。结果AD患者组血清中M-CSF水平显著高于对照组(P<0.01)和VAD患者组(P<0.05);血清M-CSF水平主要在AD早期(轻、中度痴呆阶段)升高,在AD晚期(重度痴呆)则处于正常水平。AD患者组血清中IL-1β水平明显高于对照组(P<0.05),但血清中TNF-α和IL-6处于正常水平。结论血清M-CSF水平的检测是一种方便、敏感的方法,可望作为AD患者早期诊断的生物学标志。

Objective To in vestigate the availab ility of serum level of macrophage clony stimulating factor(M-CSF)a s a marker for early diagnosis of Alzheimer' s disease(AD).Methods The serum levels of M-CSF in70patients with AD,52healthy controls,22patients with VAD(vascular dementia)were measured and the serum levels of IL-1β,IL-6,TNF-αin32patients with AD and20controls were measured as well.Results Serum levels of M-CSF were significantly elevated in patients with AD when compared with healthy controls(P<0.01)and VAD controls(P<0.05)respectively.At the early stage of mild dementia and middle dementia,serum levels of M-CSF were significantly elevated,but at the later stage of severe dementia,they returned to normal level.Serum levels of IL-1βwere significantly elevated in AD patients compared with controls(P<0.05),and serum levels of TNF-αand IL-6were within the normal range in patients with AD.Conclusions The results suggest that serum M-CSF level may provide a convenient and sensitive means for the early diagnosis of Alzh-eimer's disease.