尿吡啶啉/脱氧吡啶啉比值在骨量丢失疾病中的临床意义

EVALUATION OF URINARY PYRIDINOLINE AND DEOXYPYRIDINOLINE RATIO IN DISEASES WITH BONE LOSS

为探讨尿吡啶啉(Pyr)与脱氧吡啶啉 (Dpyr)比值变化在骨量丢失疾病中的临床意义 ,测定原发性骨质疏松症 4 8例、肿瘤骨转移者 8例及类风湿关节炎 6例 ,设 78例健康对照。结果显示 ,3种疾病患者尿Pyr和Dpyr值明显增高 (P <0 0 5 ,P <0 0 0 1) ;尿Pyr/Dpyr比值原发性骨质疏松症者无显著变化 (P>0 0 5 ) ,肿瘤骨转移者明显降低 (P<0 0 0 1) ,类风湿关节炎者明显升高 (P <0 0 0 1)。提示尿Pyr /Dpyr比值对分析不同骨量丢失疾病的骨吸收特点有临床意义。

To investigate the ratio of urinary pyridinoline (Pyr) and deoxypyridinoline (Dpyr) in diseases with bone loss, urinary Pyr and Dpyr levels were evaluated in 48 cases of osteoporosis, 8 cases of carcinoma with bone metastasis, 6 cases of rheumatoid arthritis, and 78 healthy volunteers. It was found that urinary Pyr and Dpyr increased significantly as compared to those in the control ( P <0 05,<0 001). No change was found in Pyr /Dpyr ratio in the patients with osteoporosis( P >0 05), while it was dramatically lower in the patients with carcinoma bone metastasis ( P <0 001), and was significantly higher in the patients with rheumatoid arthritis ( P <0 001). The results indicated that the ratio of Pyr/ Dpyr is very useful for the evaluation of bone absorption in different diseases with bone loss.