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肿瘤光动力疗法诱导细胞凋亡机制研究进展 被引量：47

Research progress in the study of mechanism of apoptosis induced by photodynamic therapy of tumor
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摘要 肿瘤光动力疗法 (PhotodynamicTherapy ,PDT)是利用光敏剂分子接受光照后产生多种活性氧物质 (reactiveoxygenspecies ,ROS) ,使细胞结构和功能受到损伤 ,而导致细胞凋亡的一种独特的肿瘤治疗方法 ,已受到越来越多的重视。
作者 孟斌 温博贵 李冠武 沈忠英
机构地区 汕头大学医学院分子生物学研究室
出处 《生理科学进展》 CAS CSCD 北大核心 2002年第3期269-272,共4页 Progress in Physiological Sciences
基金 国家"8 6 3"项目 (819 Q 12 ) 广东省医学科学基金(B2 0 0 0 0 92 )资助课题
关键词 肿瘤 光动力学疗法 诱导 细胞凋亡 机制 研究进展 活性氧物质
分类号 R730.59 [医药卫生—肿瘤]
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参考文献10

  • 1[1]Noodt BB, Berg K, Stokke T, et al. Different apoptotic pathways are induced from various intracellular sites by tetraphenylporphyrins and light. Br J Cancer, 1999, 79: 72～81.
  • 2[2]Chan WH, Yu JS, Yang SD. Apoptotic signalling cascade in photosensitized human epidermal carcinoma A431 cells: involvement of singlet oxygen, c-Jun N-terminal kinase, caspase-3 and p21-activated kinase 2. Biochem J, 2000, 351(Pt 1):221～232.
  • 3[3]Viola A, Lutz NW, Maroc C, et al. Metabolic effects of photodynamically induced apoptosis in an erythroleukemic cell line. A (31)P NMR spectroscopic study of Victoria-Blue-BO-sensitized TF-1 cells. Int J Cancer, 2000, 85: 733～739.
  • 4[4]Zhuang S, Demirs JT, Kochevar IE. p38 mitogen-activated protein kinase mediates bid cleavage, mitochondrial dysfunction, and caspase-3 activation during apoptosis induced by singlet oxygen but not by hydrogen peroxide. J Biol Chem, 2000, 275: 25939～25948.
  • 5[5]Xue LY, Chiu SM, Oleinick NL. Photodynamic Therapy-Induced Death of MCF-7 Human Breast Cancer Cells: A Role for Caspase-3 in the Late Steps of Apoptosis but Not for the Critical Lethal Event. Exp Cell Res, 2001, 263: 145～155.
  • 6[6]Granville DJ, Jiang H, An MT, et al. Bcl-2 overexpression blocks caspase activation and downstream apoptotic events instigated by photodynamic therapy. Br J Cancer, 1999, 79: 95～100.
  • 7[7]Xue LY, Chiu SM, Oleinick NL. Photochemical destruction of the Bcl-2 oncoprotein during photodynamic therapy with the phthalocyanine photosensitizer Pc4. Oncogene, 2001, 20: 3420～3427.
  • 8[8]Whitacre CM, Feyes DK, Satoh T, et al. Photodynamic therapy with the phthalocyanine photosensitizer Pc 4 of SW480 human colon cancer xenografts in athymic mice. Clin Cancer Res, 2000, 6: 2021～2027.
  • 9[9]Zhang WG, Li XE, Ma LP, et al. Wild-type p53 protein potentiates phototoxicity of 2-BA-2-DMHA in HT29 cells expressing endogenous mutant p53. Cancer Lett, 1999, 138: 189～195.
  • 10[10]Ahmad N, Gupta S, Mukhtar H. Involvement of retinoblastoma (Rb) and E2F transcription factors during photodynamic therapy of human epidermoid carcinoma cells A431. Oncogene, 1999, 18: 1891～1896.

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生理科学进展
2002年 第3期

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