摘要
目的 探讨 β-连接素 (β-catenin)蛋白的表达及其与膀胱移行细胞癌组织学特征和侵袭的关系。 方法 采用免疫组化 SP法检测 46例膀胱移行细胞癌组织中的β-catenin的表达。 结果 正常膀胱粘膜上皮细胞全部表达 β-catenin,膀胱移行细胞癌中 β-catenin的表达率分别是“+ + +”为 5 2 .1% (2 4/4 6) ,“+ +”为 3 2 .6% (15 /4 6) ,“+”为 15 .2 % (7/4 6)。侵袭型的膀胱移行细胞癌中 β-catenin表达率是“+ + +”为 11.1% (1/9) ,显著低于乳头状型者 (P <0 .0 1)。 结论 β-catenin的表达与膀胱移行细胞组织学特征及侵袭有相关性 ,可作为判断肿瘤恶性程度、侵袭、预后的有价值指标。
Objective To study the expression of β catenin andits relationship with the character and the invasion of transitional cell carcinoma Methods Immunohistochemistry SP was used to test the expression ofβ catenin in 46 cases of transitional cell carcinoma Results All the mucous epithelium of bladder expressed β catenin,and its rate in transitional cell carcinoma sepaately showed '+++' was 52 1%(24/46),'++' was 32 6%(15/46) and '+', 15 2%(7/46),and that of the invasive typesowed '+++' was 11 1%(1/9) which was significantly lower than that in the cases of papillary(P<0 01) Conclusions The expression of β catenin was related to the character and the invasion of the invasion of the cytohistology It can be regarded as a valuable index to decide the exted of malignant tumor,its invasion and prognosis
出处
《蛇志》
2002年第2期1-2,共2页
Journal of Snake