降纤酶治疗急性缺血性脑血管病的疗效观察

Effect Observation of defibrase Treating Acute Cerebral Infaction

目的 观察应用降纤酶治疗急性缺血性脑血管病的疗效。 方法 将急性缺血性脑血管病患者10 5例 ,随机分为治疗组和对照组。治疗组 5 4例 ,用降纤酶 10 u (体重在 60 kg以下者 5 u)加生理盐水 2 5 0 ml静脉滴注 ,每天 1次 ,连用 3天 ,第 4天后改为隔日静滴 1次 ,降纤酶总量达到 60 u;对照组 5 1例 ,用复方丹参 2 0 ml加 0 .9%生理盐水 2 5 0 ml静脉滴注 ,每天 1次 ,连用 14天为 1个疗程。于治疗后第 7天、第14天检测两组治疗前后的神经功能缺损评分和日常生活能力评分 ,以评价其临床疗效。 结果 治疗组的有效率和显效率分别达到 87.0 3 %和 62 .9% ,而对照组的有效率和显效率分别为 60 .78%和 3 7.2 5 % ,两组比较有显著性差异 (P <0 .0 5 )。两组治疗后的日常生活能力和神经功能缺损评分均有显著性差异 (P<0 .0 1) ,血液流变学等指标均有明显的改善 (P <0 .0 1)。 结论 降纤酶具有降低血浆纤维蛋白原、改善微循环、降低全血粘度等作用 ,是治疗急性缺血性脑血管病安全。

Objective To observe the efficacy of defibrase treating to acute cerebral infaction Methods The 105 patients were divided into two groups randomly Patients(n=54) as treatment group were treated with defibrase 10u added to 0 9% normal sodium 250ml,iv drip,once daily for 3 days,4 days later once every the other day,altogether 60u The other 51 patients as compound group were treated with salvia miltiorrhiza20ml added to 0 9% normal sodium 250ml iv drip, qd for 14 days We examied neurological function and ability of linving before and after treatment to evaluate the efficacy Result The clinical effective rate was 87 03% in defibrase group while 60 78% in salvia miltiorrhiza There was significant difference between the group(P<0 05) Defibrase group's curative effect was better than of salvia miltiorrhiza compound group Defibrase can remarkably improve the sooring of neurological function and ability of living Conclusion Defibrase can remarkably reduce fibrnogn blood viscosity and improve microciculation Defibrase is safe and effective drus for the treatment of cerebral infarction