转移相关基因CD44和nm23在滋养细胞疾病中的表达及临床意义

Expression of Transfer Corelation Gene CD44 and nm23 in Gestational Trophoblastic Diseases and its Clinical Significance

【目的】探讨转移相关基因CD44和nm2 3在预测葡萄胎恶变和滋养细胞肿瘤转移潜能的意义。【方法】采用SP免疫组织化学法检测 30例葡萄胎新鲜标本和 5 7例滋养细胞疾病石蜡标本中CD44v6和nm2 3H1的表达情况。【结果】①nm2 3H1在 30例葡萄胎未恶变组中的表达显著高于恶变组 (P <0 0 5 ) ;② 5 7例滋养细胞疾病的石蜡标本中 ,nm2 3H1在葡萄胎组中的表达显著高于滋养细胞肿瘤 ,而CD44v6表达与之相反 (P <0 0 5 ) ;③CD44v6在恶性滋养细胞肿瘤临床Ⅱ～Ⅲ期的表达显著高于临床Ⅰ期 (P <0 0 5 )。【结论】nm2 3的缺失可能使葡萄胎恶变可能性增大 ;滋养细胞肿瘤中CD44v6过度表达者转移潜能增强 ;CD44v6和nm2 3H1在滋养细胞肿瘤中的表达呈负相关性。

To access the significance of nm23H1 and CD44v6 in predicting the malignant transformation of hydatidiform mole and metastasis of trophoblastic tumor. Immunohistochemical SP method was used to detect the expressions of CD44 and nm23 in 30 cases verdure tissues of hydatidiform mole and 57 cases paraffin tissues of gestational trophoblastic disease (GTD) ① In 30 cases verdure tissues of hydatidiform mole, expression of nm23H1 in non malignant transforming group (NMTG) was significantly higher than that in malignant transforming group (MTG) (P<0 05);② In 57 cases paraffin tissues of GTD Expression of nm23H1 in hydatidiform mole group was significantly higher than that in trophoblastic tumor group, expression of CD44 was opposite (P<0 05);③Expression of CD44v6 at clinical stage Ⅱ～Ⅲ was significantly higher than that at clinical stage Ⅰin trophoblastic tumors. [Conclusion] The absent expression of nm23H1 has high value in predicting malignant transformation of hydatidiform mole. Abnormal expression of CD44v6 is correlated with metastasis of trophoblastic tumor. The expression of CD44v6 is negatively correlated with that of nm23H1 in trophoblastic tumor.