子宫内膜癌雌孕激素受体与临床病理分析

Analysis of Estrogen and Progesterone Receptors in Endometrial Carcinoma and its Clinicopathologic Features

【目的】探讨子宫内膜癌雌激素受体 (ER)、孕激素受体PR)与临床、病理间的关系。【方法】对 83例子宫内膜癌患者手术标本常规进行病理检查 ,同时采用免疫组化技术检测ER、PR。【结果】子宫内膜癌组织ER、PR及ER和PR同时阳性率较高 ,分别为 5 6 6 %、81 9%、5 3 0 %。绝经前子宫内膜癌组织ER、PR阳性率高于绝经后 (P <0 0 5 )。子宫内膜癌Ⅰ期ER、PR阳性率高于Ⅱ期以上者 (P <0 0 5 )。子宫内膜癌组织高分化的ER阳性率高于中低分化 (P <0 0 5 ) ,而PR阳性率与组织分化程度相关不大 (P >0 0 5 )。【结论】子宫内膜癌ER、PR阳性表达与手术病理分期、分化程度有关 ,对指导术后内分泌治疗有一定价值。

To explore the relationship between the expression of estrogen and progesterone receptors (ER/PR) in endometrial carcinoma tissue and the clinicopathologic features Routine pathological examination in 83 cases of surgical specimens of endometrial carcinoma were performed and the expression of ER/PR were detected by immunohistochemical technique at the same time The positive rates of ER/PR respectively and concurrent positive rate of ER/PR were high(56 6%, 81 9% and 53 0% respectively). The positive rates of ER/PR from pre menopausal women were higher than that from post menopausal women (P<0 05) The positive rates of ER/PR in stage Ⅰ was higher than that in stage Ⅱ and advanced (P<0 05) The positive rates of ER was higher in high histological grade than that in middle and low histological grades (P<0 05) But no significant relationship between differentiation and the positive rates of PR was found(P>0 05) [Conclusion] The positive rates of ER/PR in endometrial carcinoma are correlated with clinicopathologic stage and differentiation degree. It is of value for endocrine therapy after operation