解脲支原体感染与早产及胎膜早破的关系

Relationships Between Ureaplasma Urealyticum Infection and Preterm Labor or Premature Rupture of Membrane

【目的】探讨宫颈解脲支原体 (UU )在不同状态下与早产及胎膜早破 (PROM )的关系。【方法】通过聚合酶链反应 (PCR)对 2 10例孕妇的宫颈分泌物进行UUDNA检测 ,用酶联免疫吸附试验 (ELISA)检测孕妇血清抗UUIgM ,以两项检测结果同时阳性做为宫颈UU感染的标准 ,以UUDNA阳性而血清抗UUIgM阴性做为宫颈UU的携带状态的标准 ,并结合分娩后胎膜UU培养及病理检查 ,进一步区分宫颈UU的携带状态与感染。【结果】 2 10例孕妇中宫颈分泌物UUDNA阳性10 0例 ,占 47 6 % ,宫颈分泌物UUDNA及血清抗UUIgM均为阳性者 6 2例 ,占分娩总数的 2 9 5 % ,占宫颈分泌物阳性者的6 2 % ;感染组分别与携带组和阴性对照组比较 ,胎膜早破、早产、绒毛膜羊膜炎等不良妊娠结局的发生率明显升高 ,差异显著(P <0 0 5 ) ,而携带组与阴性对照组相比 ,无显著差异 (P >0 0 5 )。【结论】宫颈UU发生感染与早产胎膜早破的发生密切相关 ;携带状态与其无相关性。

To evaluate the relationships between ureaplasma urealyticum (UU) infection and preterm labor or premature rupture of membrane (PROM). In this study, polymerase chain reaction (PCR) was used to examine the UU DNA in cervical secretion, and ELISA was used to examine serum antibody of UU IgM in 210 asymptomatic pregnant women. UU infection was diagnosed when the above two assays were positive, and carrying status was defined as cervical UU DNA positive and serum antibody of UU IgM negative. Further identification of UU infection or UU carrying status was made based on the results of UU culture and pathological examination in fetal membranes. 100 of 210 (47 6%) patients with UU DNA positive, 62 of 210 (29 5%) patients with UU DNA UU IgM positive were found. The infected group had a significantly higher rate of PROM, preterm labor, or chorioamnionitis (CMA) than that of the carrying group or the negative group (P<0 05), but no significant difference between the carrying group and the negative group was found (P>0 05). [Conclusion] Ureaplasma urealyticum infection is responsible for preterm labor or PROM.