乙胺基二(亚甲基膦酸)的合成

SYNTHESIS OF ETHYLIMINODI (METHYLENEPHOSPHONICACID)

三氯化磷、盐酸乙胺和甲醛水溶液发生Mannich反应,合成乙胺基二(亚甲基膦酸),反应的较佳摩尔比是EtNH_3CL:CH_2O:PCL_3=1:3:2.2;反应历程为甲醛先和盐酸乙胺缩合生成三乙基六氢均三嗪,后者在酸催化下裂解形成亚胺正离子,与亚磷酸发生亲核加成反应得到乙胺基二(亚甲基膦酸).

Ethyliminodi(methylenephosphonic acid)(EIDMP)was synthesized by the Mannich reaction using EtNH_3CL,formalin,and PCL3.Optimum molar ratio of reactants is EtNH_3CL:CH_2O :PCL_3=1:3: 2.2.The mechanism of formation of EIDMP was studied:EtNH_2 is condensed with CH_2O to yield a intermediate, 1,3,5-triethylhexahydro-striazine.This intermediate is cleaved under acidic catalysis to give methyleniminum ions, and then the addition of H_3PO3 acting as a nucleophile to the ions occurs to produce EIDMP.