碘盐对药物治疗Graves病疗效的影响

Effect of iodized salt on treatment with antithyroid drugs in Graves' disease

目的 探讨碘盐对抗甲状腺药物 (ATD)治疗 Graves病 (GD)疗效的影响 ,从而为临床上碘盐的合理应用提供依据。方法 将 4 9例 GD患者随机分为食用非碘盐组和食用碘盐组 ,予 ATD治疗并定期测定心率、体重、甲状腺肿大程度、Graves眼病分级、血清 T3、T4 、FT3、FT4 、TSH、TGA、MSA、TRAb,连续观察 6个月后 ,分析比较两组检查结果。结果 1非碘盐组与碘盐组患者比较 ,甲状腺肿大和 Graves眼病非碘盐组患者好转更明显 ,差异有显著意义 (P <0 .0 5 ) ;2非碘盐组患者治疗后 6个月血清 TRAb下降 ,与治疗前比较差异有显著意义(P <0 .0 5 ) ,而碘盐组患者治疗前后血清 TRAb差异无显著意义 (P >0 .0 5 ) ;3非碘盐组患者血清 TGA、MSA有降低趋势 ,但与碘盐组比较差异无显著意义 (P>0 .0 5 ) ;4碘盐对 GD患者血清甲状腺激素影响不大 ,对心率、体重变化无影响。结论 食用非碘盐有利于控制 GD患者的病情 ,提示 GD患者

Objective To study the effect of iodized salt on treatment with antithyroid drugs in Graves' disease.Methods Patients were randomly assigned to receive salt without iodine (group A) or iodized salt (group B). A clinical and laboratory assessment was performed on the day before treatment and on months 1?2?3?4?5?6 after treatment.Results ①Better results were achieved in patients in group A than in group B on their enlarged thyroid and proptosis. ②The levels of TRAb were significantly lower in patients in group A after treatment compared with those before the treatment (P<0.05), but the difference in group B was insignificant (P>0.05). ③The levels of TGA and MSA were insignificantly lower in patients in group A compared with group B (P>0.05). ④There is little difference in changes of the serum thyroid hormone levels as well as heart rate and weight between the patients in two groups.Conclusions Salt without iodine could help patients in Graves' disease to achieve better results. So, salt without iodine was highly recommended during the treatment with antithyroid drugs in Graves' disease.