苯并(a)芘和芘的混合物暴露对梭鱼肝脏抗氧化酶活性的影响

Effects of mixture of benzo(a)pyrene and pyrene exposure on hepatic antioxidant enzymes activities in Mugil so-iuy

在实验生态条件下 ,研究浓度范围从 0 1— 5 0 μg L的苯并 (a)芘和芘的等浓度混合物暴露对梭鱼 (Mugilso iuy)肝脏抗氧化酶活性的影响 .结果显示 ,对肝脏谷胱甘肽过氧化物酶 (GPx)和超氧化物歧化酶 (SOD)活性的影响主要表现出抑制效应 .在暴露过程中 ,抗氧化酶活性也有出现短暂的诱导 ,高浓度组出现诱导的时间比低浓度组早 .SOD和GPx活性的变化有一定的同步性 .CAT活性在暴露早期出现诱导 .抗氧化酶活性的变化间接反映了环境中氧化胁迫的存在 .

The effects of the mixture of benzo(a)pyrene and pyrene (concentration range of 0 1—50*!μg/L) exposure on hepatic antioxidant enzymes activitives in Mugil so-iuy were studied under experimental condition.The results mostly showed that the activities of glutathione peroxidase (GPx) and superoxide dismutase (SOD) were inhibited. The activities of the antioxidant enzymes were sometimes induced briefly during exposure. The enzyme activities induction appeared sooner at higher concentration group than that at lower concentration group. The SOD and GPx activities changed quite in phase. The CAT activity was induced at the early exposure. The changes of antioxidant enzymes activities reflected indirectly the existence of oxidation stress.