旱前胡的化学成分

CHEMICAL CONSTITUENTS OF THE CHINESE DRUG HAN-QIAN-HU (LIGUSTICUM DAUCOIDES)

从云南产早前胡(Ligusticum daucoides Franch.)(伞形科)根的脂溶性部分分离了11个化合物,分别为香豆素化合物:columbianadin,isoedultin,archangelicin,旱前胡甲素(daucoidin A),旱前胡乙素(dsucoidin B),佛手柑内酯(bergapten),非香豆素化合物:falcarindiol(7),阿魏酸(ferulic acid),蜡酸(cerotic acid),β-谷甾醇(β-sitosterol),胡萝卜甙(daucosterol)。其中,化合物4和5是新的香豆素化合物,经化学方法及光谱测定,证明其结构为:4是3′去乙酰基isoedultin,即:2′(S)-(1″,1″-二甲基,1″-当归酰氧基)-3′(R)-羟基-角型二氢呋喃香豆素[2′(S)-(1″,1″-dimethvl,1″-angelovloxv)—3′(R)-hydroxy angular dihydrofuranocoumarin];5是2′-(1″-甲基,1″-羟基,1″-当归酰氧亚甲基)-角型二氢呋喃香豆素[2′-(1″-methyl,1″-hydroXy,1″-angeloyloxy-methylene)angular dihydrofuranocoumarin]。

Eleven compounds, two new angular dihydrofuranocoumarins and four known coumarins together with other five known compounds, which have been isolated from the chinese drug Han Qian-Hu (Ligusticum daucoides F ranch.). The new coumarins, named daucoidin A(4) and tiaucoidin B(5), have been elucidated as 2'(S)-(1', 1'-dimethyl, 1'-angeloyloxy) -3' (R)-hydroxy argular dihydrofur- anocoumarin( 4 ) and 2'-(1' -methyl, l'-hydroxy, l'-angeloyloxymcthylcnc) angular dihydrofuranocoumarin( 5 ) by means of spectral analysis.