不同甲状腺功能状态血清瘦素水平的变化

Changes of serum Leptin levels in different thyroid functional status

目的 :探讨不同甲状腺功能状态 (甲亢、甲减、正常 )血清瘦素 (Leptin)水平的变化。方法 :采用放射免疫分析法 (RIA)分别检测 30例甲状腺功能亢进、30例原发性甲状腺功能减退和 30例健康人血清Leptin水平。结果 :甲减组的Leptin水平 [(3.95± 1.76 ) μg/L]明显低于健康组 [(7.98± 3.0 1) μg/L],差异有显著性(P <0 .0 1) ;而甲亢组Leptin水平 [(8.0 1± 2 .84) μg/L]与健康组比较差异无显著性 (P >0 .0 5 )。 结论 :甲减患者血清Leptin水平明显下降 ,而甲亢患者则无变化。Leptin与甲状腺激素有一定的关系。

Objective:To study the changes of serum Leptin levels in different thyroid functional status(hyperthyroidism and hypothyroidism and normal controls )Methods:The levels of Leptin was determined by radio-immuno assay(RIA) in 30 cases of hyperthyroidism,30 cases of hypothyroidism, 30 cases of normal controls. Results:The mean levels of serum Leptin in hypothyroidism[(3.95±1.76)μg/L] were significantly lower than healthy subjects[(7.98±3.01) μg/L](P<0.01); There were no statistical difference between the hyperthyroidism[(8.01±2.84) μg/L] and healthy subjects(P>0.05).Conclusion:The levels of serum Leptin in hypothyroidism markedly descend and no changes in hyperthyroidism. Leptin might play an important role in the hypothyroidism. [FK(WB80011?6]