肝硬变门静脉高压症患者血中内皮素与前列环素相互关系的临床研究

Clinical study of relationship between ET and PGI_2 in cirrhotic patients with portal hypertension

目的 探讨肝硬变门静脉高压症患者血中内皮素 (endothelin ,ET)与前列环素 (prostacyclin ,PGI2 )间相互作用关系及病理生理意义。方法 观察 12例肝硬变门静脉高压症患者门腔分流术后 ,消炎痛对门脉压力、血浆ET和PGI2 的作用。结果 用消炎痛后 ,门脉压力、门脉血浆ET水平明显升高 ,PGI2 水平明显下降 (P <0 .0 0 1)。结论 提示PGI2 能有效拮抗ET的生物学效应 ,血管内皮细胞所释放的PGI2 与ET间可能存在反馈调节。

Objective To investigate the interaction between prostacyclin(PGI 2) and endothelin (ET) in cirrhotic patients with portal hypertension and its pathophysioplogical significance.Methods The changes of portal pressure,portal plasma ET and PGI 2 were observed after indomethacin administration in 12 cirrhotic patients with portal hypertension undergoing portasystemic shunt.Results It was found that portal pressure and portal plasma ET level were increased and PGI 2 concentration were reduced( P <0.001).Conclusion It is indicated that PGI 2 antagonizes biological actions of ET effectively,which suggested that a feedback mechanism could exist in vivo between ET and PGI 2 released from vascular endothelial cells.