血清总胆汁酸水平对原发性高血压致病作用的探讨

A study on pathogenic factor of serum bile acid levels in essential hypertension

目的探讨血中总胆汁酸在原发性高血压患者中的致病作用。方法采用酶法检测 6 0例健康人、10 2例原发性高血压患者及 30例继发性高血压患者的血清总胆汁酸水平并作对比分析。结果原发性高血压患者组血清总胆汁酸水平较正常对照组及继发性高血压患者组均显著升高 (P <0 0 1)。其中有高血压家族史者较无高血压家族史者明显升高 (P <0 0 1) ;Ⅲ级高血压患者血清总胆汁酸水平较Ⅰ级和Ⅱ级高血压患者明显升高 (P <0 0 1) ;Ⅱ级高血压患者血清总胆汁酸水平与Ⅰ级高血压患者血清总胆汁酸水平虽有升高 ,但无统计学意义。继发性高血压患者组血清总胆汁酸水平与正常对照组比较无差异 (P >0 0 5 )。结论血中总胆汁酸水平升高可能参与原发性高血压的发病过程。

Objective To investigate the role of total bile acid (TBA) in pathogenesis of essential hypertension. Methods The concentration of serum TBA was measured by enzymatic method in 192 cases including 60 healthy controls, 102 essential hypertensive patients and 30 secondary hypertensive patients. Results The levels of serum TBA in essential hypertensive group were significantly higher than theoe of control group and secondary hypertension ( P <0.01). No significant difference was found in TBA levels between secondary hypertension and control group( P >0.05). In essential hypertensive group, there was a significant increase of TBA in familial patients compared with that of non-familial patients( P <0.01). The levels of TBA in grade-3 hypertension were significantly higher than those of grade-2 and grade-1 hypertension ( P <0.05). No significant difference was found in TBA levels between grade-2 and grade-1 hypertension( P >0.05). Conclusion The increase of TBA may play an role in pathogeneses of essential hypertension.