E,E-1-(3'-吲哚基)-5-取代苯基-1,4-戊二烯-3-酮化合物的合成及抗炎活性

Synthesis and Anti-inflammatory Activity of E,E-1-(3'-Indolyl)-5-(substituted phenyl)-1,4-pentadien-3-one Derivatives

合成了 9个 E,E-1 -(3 -吲哚基 ) -5 -取代苯基 -1 ,4-戊二烯 -3 -酮化合物 ,通过 MS、1H NMR、UV等对其进行了表征 .药理筛选结果表明 ,其中一些化合物对小鼠耳部巴豆油炎症具有一定的抑制作用 .

Nine E,E 1 (3 indolyl) 5 (substituted phenyl) 1,4 pentadien 3 one derivatives were synthesized and characterized by MS, 1H NMR and UV. Five of these compounds(1,3,4,6,7) showed a certain anti inflammatory activity on mouse ear edema induced by croton oil with the inhibitions being 21 1%, 25 3%, 18 4%, 22 3% and 28 9% respectively ( P <0 05 or P <0 01 vs control), at the hypodermic injection dose of 50 mg/kg.