钒化合物生物效应的化学基础和药用前景——金属药物研究的化学问题

Biological Effects of Vanadium and Its Potential for Pharmaceutical Applications ——The Chemical Issues in the Studies of Metal Drugs

本文从非必需元素的相似性作用规律的观点 ,综述了钒在生理条件下的物种变化和决定其生物效应的基本化学性质 ,对钒化合物的类胰岛素活性、作用机制和钒抗糖尿病药物研究进行了介绍。

In light of the analogy in chemical and biological behavior between non-essential ions and essential ions, the chemical species of vanadium compounds under physiological condition and their physical-chemical characters, which are important for the biological effects are reviewed. The mechanisms of hypoglycemic activity of insulin-mimic vanadium compounds and development of anti-diabetes drugs are also introduced.