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不同宫颈组织中nm23-H1表达 被引量:2

Expression of nm23-H1 Gene in Different Cervical Tissues
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摘要 目的 探讨不同宫颈组织中 nm2 3- H1表达 ,旨在了解 nm2 3- H1在宫颈癌发生发展及预后的作用。方法 采用免疫组化法 HIGH- SABC法检测宫颈鳞状上皮癌 (SCC) 5 0例、低度不典型增生 (CIN 、CIN )及重度不典型增生(CIN )各 15例、正常宫颈鳞状上皮组织 10例中 nm2 3- H1的表达。结果 正常宫颈组织和低度不典型增生中 nm2 3- H1阳性表达率均明显高于 SCC(P<0 .0 5 ) ,CIN 中 nm2 3- H1阳性率明显减少 ,与 SCC相比 ,两者间无统计学差异。 SCC中 nm 2 3- H1的表达与癌细胞分化程度呈负相关 ,与其他参数和预后不相关。结论  nm2 3- H1的低表达在宫颈鳞癌序列发生发展中可能起一定作用 ,但不能作为宫颈鳞癌预后评价指标。 Objective To expore the expression of nm 23-H1 gene and its s ignificance in different cervical tissues.Methods Expressions o f nm23-H1 gene protein in 50 cases with squmous cell carcinoma(SCC),15 with low-gradesqua mous dysplasia of the cervix(CINⅠ?CINⅡ) and high-grade squamous dysplasia of the cervix(CINⅢ) respectively and 10 with normal tissue of the uterine cervix we re examined by immuno-histochemical staining.Results Positive rate of nm23-H 1 protein was significant higher in normal cervica l tissue and low-grade CIN t han that in SCC,and significantly lower in all of the high-grade CIN,However,th ere was no statistically significant difference in nm23-H1 immunoreactivity b etween cases of high-grade CIN and SCC.nm23-H1 gene protein only negatively co rrelated with cell differentiation and there was no statistic relation with othe r clinicopathology parameterd and prognosis.Conclusion These fi ndings suggested that the reduced expression of nm23-H1 might be important in the sequential de velopment of cervical squamous neoplasia,however,it may not be regard as an usef ul marker predicting prognosis of squmous cell carcinoma.
出处 《中国误诊学杂志》 CAS 2002年第7期991-992,共2页 Chinese Journal of Misdiagnostics
关键词 宫颈肿瘤 病理学 宫颈癌 NM23-H1基因 基因表达 肿瘤发生 预后 免疫组织化学 Cervix neoplasms/pathology Carcinoma,squamous cell/pathology Transcription factors/metabolism
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  • 1雷文东,中华肿瘤杂志,1994年,16卷,277页
  • 2张惜阴,临床妇科肿瘤学,1993年,99页

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