生长激素受体在人肝癌组织中的表达

The Expression of Growth Hormone Receptor in Human Hepatocellular Carcinoma

目的 研究人类肝癌细胞中是否存在生长激素受体 (GHR)。方法 采用免疫组织化学方法 ,对 5 0例肝细胞肝癌标本 ,49例癌旁肝组织 ,3 0例肝硬变组织及 3 0例正常肝组织进行GHR的测定。结果 肝癌标本中 42 .0 %存在GHR阳性表达 ,其中仅 2 2 .0 %的标本存在中到强阳性表达。癌旁肝组织中GHR阳性染色占 95 .9% ,肝硬变组织中占96.7% ,正常肝组织占 93 .3 %。结论 肝癌患者中存在GHR的低度表达 ,因此 ,在对行肝癌根治性手术后或肝癌细胞GHR表达阴性的患者术后可使用生长激素治疗。

Objective To explore whether the growth hormone receptor (GHR) is present in human hepatocellular carcinoma (HCC). Methods The GHR were measured in samples of human HCC (50 cases), the liver tissues adjacent to hepatocellular carcinoma (49 cases), cirrhotic liver tissues (30 cases) and control liver tissues (30 cases) by immunohistochemistry technique. Results The GHR positive expression rate was 42.0% in samples of human hepatocellular carcinoma, and 95.9% in adjacent tissue of HCC, 96.7% in cirrhotic liver tissues, and 93.3% in normal liver tissues; the significance of the differences in the GHR positive expression rate was seen between HCC and the compared groups.Conclusion The lower expression of GHR in HCC is present. The growth hormone administration can be used in patients of HCC with radical resection or GHR negative expression patient.