家兔静注环丙沙星后血液与眼组织分布及其药代动力学研究

Distribution and pharmacokinetics after intravenous injection of ciprofloxacin in the rabbit eye

研究家兔静注环丙沙星 (CPL X)后血液与眼组织分布及药代动力学参数。用高效液相色谱法测定血液和眼内各组织中药物浓度。结果给药 30 min后泪液、角膜、房水、虹膜 -睫状体、晶状体和玻璃体组织内峰浓度值 (Cmax)分别为 (8.92± 2 .88)、(14 2 .84± 2 5 .0 2 )、(11.0 6± 2 .80 )、(99.32± 10 .6 0 )、(30 .2 8± 1.91)和(8.10± 1.71) μg/ ml或 μg/ g;其血液和各组织中消除半衰期 (T1 /2β)分别为 (1.2 1± 0 .2 3)、(1.4 8± 0 .97)、(1.6 6± 0 .13)、(2 .0 9± 0 .5 1)、(2 .0 1± 0 .4 4 )、(1.5 2± 0 .92 )和 (1.2 1± 0 .6 6 ) h。表明家兔静注 CPL X后能穿透到眼内各组织中。

To study the blood or intraocular distribution and pharmacokinetics of intravenously administered ciprofloxacin in rabbits′ eyes. The blood or intraocular concentrations of ciprofloxacin were measured by high performance liquid chromatography (HPLC). The peak concentrations ( C max ) of ciprofloxacin in lachrymal fluid, cornea, aqueous humor, iris ciliary body, lens, vitreous body were (8.92±2.88), (142.84±25.02), (11.06±2.80), (99.32±10.60), (30.28±1.91) and (8.10±1.71)μg/ml(μg/g) respectively. The half life ( T 1/2β ) of various concentration in blood, lachrymal fluid, cornea, aqueous humor, iris ciliary body, lens and vitreous body was (1.21±0.23), (1.48±0.97), (1.66±0.13), (2.01±0.51), (1.52±0.92), and (1.21±0.66)h, respectively. Results indicate that ciprofloxacin can penetrate various intraocular tissues.