摘要
探讨宣发膜原方对CIA的治疗机理 ,为研究RA的发病和损伤机理提供实验依据。以CIA作为RA的动物模型 ,对比研究宣发膜原方和雷公藤制剂对CIA大鼠免疫指标的影响。宣发膜原方和雷公藤制剂都可以减轻CIA大鼠病理损伤 ,增加血清中IFN γ ,降低TNF α和抗CII抗体 ,并且雷公藤制剂对CIA的治疗效果不如宣发膜原方作用快。宣发膜原法能够减轻CIA病理损伤 ,调节CIA大鼠免疫功能。
To probe the mechanism of Xuanfa Moyuan preparation treating rats collagen\|Ⅱ inuced arthritis(CIA)which is similar to human RA,rats were immunized with the complex of collagen\|Ⅱ and complete Frund's adjuvant.The immunological and morphological changes in the rats were observed after the rats were treated with Xuanfa Moyuan preparation common threewingnut root,damages of CIA rats joints were relieved,TNF\|α and anti\|CII antibody in the serum showed some decrease.But IFN\|γ showed some increase.Xuanfa Moyuan prepartion could relieve the damages of CIA rat's joints and regulate the immunology activity of CIA rats.And Xuanfa moytan preparation could produces effect more quickly than common threewingnut root.
出处
《中国实验方剂学杂志》
CAS
2002年第4期21-24,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金资助项目 (3 9870 95 2 )
