滋水降火饮镇静、降血压药效研究

Pharmacodycamics Research on ZiShuijiangHuo Ying(ZSJHY)

探讨滋水降火饮对高血压大鼠的防治作用 ,观察滋水降火饮镇静安神作用和以两肾一夹高血压大鼠 (2K1C RHR)的降压、逆转左心肥厚和减轻靶器官损害作用。滋水降水饮能明显延长戊巴比妥钠小鼠的睡眠时间 ,增加睡眠只数 ,抑制小鼠的自发活动 ;预防性治疗可延缓 2K1C RHR血压的升高 ;经 8周治疗 ,2K1C RHR的血压有不同程度的降低 ,左心肥厚有一定程度逆转。

to study the effect of ZiShuijiangHuoYing(ZSJHY) on 2K1C\|RHR,we observed composure and hypnosis effect,prophylactic treatment therapeutic action,reversing left ventricular hypertrophy(LVH)and observation target organ damages on 2K1C\|RHR by giving ZSJHY.It could prolong significantly sleep time of mice,increased sleep population,and restrained mice autogenesis.After 8 week from making 2K1C\|RHR model,ZSJHY could postpone raise of 2K1C\|RHR blood pressure and maintain its effect about 7 days after stopping used ZSJHY.