中药双龙丸对冠心病患者颈动脉粥样硬化的影响

Effect of Shuanglongwan(SLW)on the Carotid Atherosclerosis of the Patients with Coronary Heart Disease(CHD)

目的 :颈动脉动脉粥样硬化与冠状动脉粥样硬化有密切关系。为了评价中药双龙丸对动脉粥样硬化的临床疗效 ,我们采用彩色超声多普勒观察双龙丸对颈动脉粥样硬化的影响。方法 :临床选择 5 2例有颈动脉动脉粥样硬化的冠心病患者。随机分为双龙丸治疗组和开博通对照组。观察颈动脉内中膜厚度 (IMT)及截面积、斑块厚度及面积 ,以及血流参数的变化。结果 :经双龙丸治疗后 ,IMT由 1 32mm降低到 1 16mm ,平均降低 0 16 2mm ;内中膜截面积由 4 4 2 3mm2 减少到 38 11mm2 ,斑块厚度由 2 4 6mm减少到 1 88mm ,平均减少 0 5 7mm ;斑块面积由 4 5 89mm2 减小到 36 83mm2 ,治疗前后有显著性差异 ;而对照组治疗前后变化不明显。结论 :双龙丸能降低颈动脉动脉粥样硬化的内中膜厚度、斑块厚度及面积。双龙丸有阻止动脉动脉粥样硬化发展的作用。

patients with CHD were randomly divided into SLW group and captopril control group.The status of the carotid vessel wall and the blood flow parameter were observed.Results showed the intima\|media thickness(IMT)reduced to 0.162mm,the area of plaque reduced from 45.89mm\+2 to 36.83mm\+2( P <0 05)after treatment by SLW.There was no significant change before and after treatment by captopril( P >0 05).It was also not significant difference in blood flow parameter.