国人丙泊酚ED_(50)和EC_(50)的测定及年龄的影响

Determining hypnotic ED_(50) and EC_(50) of propofol and the influence of age in Chinese

目的 测定国人丙泊酚麻醉诱导时患者呼之不应的 5 0 %有效剂量 (ED50 )和 5 0 %有效浓度 (EC50 ) ,并确定年龄对ED50 和EC50 的影响。方法 90例不用术前药的患者 ,按年龄分为青年组(A组 :18～ 39岁 )、中年组 (B组 :40～ 6 4岁 )和老年组 (C组 :6 5～ 80岁 ) ,每组再根据丙泊酚剂量0 5、0 7、0 9、1 3、1 7mg/kg分为 5个亚组 ,经左肘静脉注入丙泊酚后 1、2、3、4、5分钟评价患者的反应并且抽取静脉血测定血浆浓度 ,然后确定丙泊酚剂量、血浆浓度与呼之不应之间的关系。结果 年龄显著影响丙泊酚的ED50 和EC50 ,患者呼之不应的ED50 和EC50 在A、B、C三组间差异显著 ,A <B<C(P <0 0 5 )。国人丙泊酚麻醉诱导时患者呼之不应的ED50 和EC50 按年龄 18～ 39岁、40～ 6 4岁、6 5～ 80岁分别是 1 0 7、0 93、0 70mg/kg和 3 91、2 47、2 0 0 μg/ml。 结论 随年龄增加 ,患者呼之不应的丙泊酚ED50 和EC50

Objective To determine the effects of age on the 50% effective dose(ED 50) and 50% effective concentration(EC 50) of propofol for hypnosis in Chinese.Methods Ninety unpremedicated patients was allocated into one of three age groups,18-39yr(A),40-64yr(B),and 65-80yr(C) respectively.Patients in each group were sedated with propofol at five predetermined dose 0.5mg/kg,0.7mg/kg,0.9mg/kg,1.3mg/kg and 1.7mg/kg.Venous blood samples for analysis of plasma propofol concentration were taken at 1,2,3,4 and 5min after propofol injection and estimate the response of patients simultaneously.The relationship between doses,concentrations of propofol and responses to a verbal command were determined.Results Aging significantly affected both ED 50 and EC 50.ED 50 and EC 50 values of propofol for loss of conscious defined as no response to a verbal command were significantly different among A,B,C each other,A<B<C(P<0.05).ED 50 and EC 50 values of propofol for loss of conscious are 1.07mg/kg,0.93mg/kg,0.70mg/kg and 3.91μg/ml,2.47μg/ml,2.00μg/ml respectively.Conclusion Aging reduce ED 50 and EC 50 to suppress response to a verbal command.