术前肠外营养结合动脉化疗对胃癌微血管密度的影响

Influence of microvessel density of parenteral nutrition with selective intra-arterial chemotherapy in gastric cancer

目的 :探讨术前短期 (7天 )肠外营养结合选择性动脉介入化疗对胃癌微血管密度 (MVD)的影响。 方法 :对 1996年至 2 0 0 0年间 6 0例进展期胃癌的临床资料进行回顾性分析 ,将 6 0例病人分成四组 :肠外营养结合介入化疗组、肠外营养组、单纯介入化疗组及对照组。用Ⅷ因子抗体作病理切片的免疫组织化学染色 ,在显微镜下进行MVD计数。 结果 :经 7天治疗后 ,肠外营养结合介入化疗组的MVD值为 33± 11,肠外营养组为 5 6± 17,单纯介入化疗组为 31± 12 ,对照组为 5 4± 18。肠外营养结合介入化疗组及单纯介入化疗组的MVD值明显低于肠外营养组及对照组 (P <0 .0 1)。 结论 :术前短期肠外营养 (7天 )结合介入化疗可降低胃癌的MVD。

Objectives:To evaluate the microvessel density(MVD) of preoperational use of parenteral nutrition(PN) and selective vascular chemotherapy in the patients with gastric carcinoma. Methods:The clinical data of 60 patients with advanced gastric cancer from 1996～2000 were analyzed retrospectively and divided into 4 groups:PN combined with chemotherapy group,PN group, chemotherapy group and control group. Under light microscopy,the microvessel density was analysed immunocytochemically with antibody against factor Ⅷ. Results:The MVD of PN combined with chemotherapy group or chemotherapy group was significantly lower than that of PN group or control group( P <0.01). Conclusions:Preoperative parenteral nutrition of short term(7 days) and chemotherapy could decrease MVD of gastric carcinoma.