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部分肠外营养支持对肝硬化治疗作用的研究 被引量:10

Influence of partial parenteral nutrition with fat emulsion on liver function and energy metabolism of cirrhotic patients
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摘要 目的 :探讨糖 脂双能源部分肠外营养 (PPN)对肝硬化肝功能及能量代谢的影响。 方法 :6 7例肝硬化病人随机分为含脂组 (33例 )与对照组 (34例 ) ;按组别给予含或不含脂肪乳剂的PPN支持治疗 2周 ;PPN前后分别测定肝功能及糖、脂、能量代谢等各项指标。 结果 :治疗后与治疗前比较 ,含脂组谷丙转氨酶 (ALT)与总胆红素 (TB)、餐后 2h血糖与空腹血胰岛素水平明显下降 (P <0 .0 5 ) ,血清脂质无明显变化 (P >0 .0 5 ) ,部分血清载脂蛋白与脂蛋白水平基本恢复正常 (P <0 .0 5 ) ,血清卵磷脂胆固醇酯酰转移酶 (LCAT)活性有所恢复 (P <0 .0 5 ) ,动脉血酮体比值 (AKBR) <0 .7者AKBR可恢复 ;对照组白蛋白 (Alb)、磷脂 (PL)明显下降 (P <0 .0 5 ) ,其余指标无明显变化。 结论 :糖 Objectives:To evaluate the effect of partial parenteral nutrition(PPN) with fat emulsion on liver function and energy metabolism in patients with liver cirrhosis. Methods:67 cirrhotic patients were divided into two groups randomly and given PPN with(group 1, 33 cases) or without(group 2, 34 cases)fat emulsion for two weeks separately.Their liver function test,fasting blood glucose(FGB) and insulin(Ins) and postprandial blood glucose at 2nd hour (PPBG 2 h),lipid metabolism and arteral ketone body ratio(AKBR) were examined respectively before and after PPN. Results:Having been given PPN for two weeks,ALT and TB levels were decreased in group 1( P <0.05) but not changed in group 2( P > 0.05 ). Alb level was decreased in group 2( P <0.05). PPBG 2 h and fasting Ins levels were lower in group 1( P < 0.05 ) but unchanged in group 2( P >0.05). TG,CH and PL levels were normal in group 1( P <0.05),but PL level was lower in group 2( P <0.05). APO A 1,APO B 100 ,HDL C and VLDL C levels were increased in group 1( P <0.05) but still lower in group 2. LCAT activity was raised in group 1( P <0.05) but not changed in group 2( P >0.05).AKBR was increased in group 1( P <0.05) but still lower in group 2. Conclusions:Administration of PPN with fat emulsion for patients with liver cirrhosis might make more improvement on liver function and energy metabolism than PPN without fat emulsion.
出处 《肠外与肠内营养》 CAS 2002年第3期161-164,共4页 Parenteral & Enteral Nutrition
关键词 治疗作用 肝硬化 脂肪乳剂 肠外营养 Liver cirrhosis Fat emulsion Parenteral nutrion
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