摘要
目的 :探讨凝血因子V基因G16 91A突变 (Leiden突变 )和凝血酶原基因G2 0 2 10A突变与下肢深静脉血栓形成的关系。方法 :采用PCR RFLP技术对 86例下肢深静脉血栓形成患者和 10 0例正常对照的健康人群进行凝血因子V基因G16 91A突变和凝血酶原基因G2 0 2 10A突变检测。结果 :86例下肢深静脉血栓形成患者和 10 0例正常对照组中均未检出凝血因子V基因G16 91A突变和凝血酶原基因G2 0 2 10A突变。结论 :凝血因子V基因G16 91A突变和凝血酶原基因G2 0 2
Objective:To study the Factor V Leiden , the G20210A mutation of Prothrombin gene and their association with deep vein thrombophilia. Methods: PCR-RFLP analysis was conducted to examine mutation with 86 deep vein thrombophilic patients and 100 health controls. Results: The Factor V Leiden and the mutation of G20210A prothrombin gene were not detectable in any of the patients and controls. Conclusion: The Factor V Leiden and the mutation of G20210A prothrombin gene may not be a significant risk factor for deep venous thrombophilia in Chinese.
出处
《山东大学学报(医学版)》
CAS
2002年第3期235-237,共3页
Journal of Shandong University:Health Sciences