噻二唑类席夫碱配合物的合成及其抗超氧阴离子活性

Synthesis and the Free Radical Inhibition Rate to O^(·-) of Shift Base Containing Thiadiazole and Its Complexes of Cu(II), Zn(II) and Co(II)

天然SOD普遍存在稳定性差 ,分子量大 ,不容易透过细胞膜 ,且有免疫原性等缺点 ,使其应用受到限制 ,所以SOD模拟物的研究已成为广泛关注的课题。笔者合成了由 2 -氨基 - 5 -巯基 - 1,3,4-噻二唑和水杨醛缩合的含噻二唑类新型席夫碱配体H2 L及其与Cu(Ⅱ )、Co(Ⅱ )、Zn(Ⅱ )的配合物 ,用元素分析、红外光谱、紫外可见光谱和摩尔电导等测试对所有化合物进行了表征 ;同时 ,采用NBT法对各配合物在各种浓度下的抗超氧阴离子自由基活性进行了测定 。

The disadvantages of lower stability, macro molecular weight, lower penetrability and immunogenic property restrict the natural SOD's application, so the researches of SOD have been being paid close attention to by scientists and engineers. Form 2-amino-5-mercapto-1,3,4-thiadiazole and salicylaldehyde, a new Schiff base containing thiadiazole is synthesized. With the Schiff base ligand, the complexes of Cu(Ⅱ), Zn(Ⅱ) and Co(Ⅱ) are prepared. The compounds have been characterized by elemental analysis, IR, UV-Visible spectra and conductivity measurements. The free radical inhibition rate to O·- have also been tested by NBT method. The results show that all of the obtained complexes displayed significant activities and the copper(Ⅱ) complexes showed the best inhibitive effect.