强迫振荡技术对哮喘病人肺功能测定的临床观察

Clinical Observation Lung Function Estimated by Forced Oscillation Tedmique in Patients with Asthma

目的探讨哮喘病人发作期和缓解期的肺通气功能以及通过强迫振荡技术测定气道阻力的变化水平。方法使用德国Custo-vitm系统设备,测定8Hz振荡频率的气道阻力以及用力肺活量(FVC),一秒钟用力呼气容积(FEV_1)最大呼气流速(PEF),一秒钟用力呼气容积占用力肺活量比值(FEV1％)以及排出50％肺活量后用力呼气流量(FEF_(50)％)。然后分别对发作期和缓解期哮喘病人进行统计学比较。结果病人缓解期肺通气指标较发作期有明显改善(P<0.01),气道阻力也有改善(P<0.05)。32例临床缓解期气道阻力高于正常的哮喘患者,其缓解期肺通气指标较发作期有明显改善(P<0.01),气道阻力变化无显著性差异(P>0.05)。结论应用强迫振荡技术进行气道阻力测定,在方法上明显优于传统的肺功能检测,所测的气道阻力能更准确地反映肺功能的实际情况。

Objective To discuss the changes of airway resistane measured by the technique of the forced oscillation and the changes of pulmonary ventillation at the onset and remission of patients with asthma.Method Used Gusto - vital forced oscillation device manufactured in Germany to detect airway resistane at 8HZ oscillatory frequency and examined pulmonary ventilation functions which include FVC, FEV1, PEF, FEV1 % and FEF 50% .The results were compared separately between the onset and remission in patients with asthma. Result The indexes of pulmonary ventilation function at the remission of patients with asthma were obviously better than those at the onset of patients with asthma (P<0.01) .and airway resistane was also better (P < 0.05) . But in 32 cases, airway resistance at the remission was higher than that of normal, the indexes of pulmonary function at the remission were markedly ameliorated compared with those at the onest (P< 0.01), but the change of airway resistance was not significantly differente (P> 0.05) .Conclusion The technique of forced osillation applied to measure airway resistance precedes the conventional pulmonary function test and the measurements of airway resistance can more accurately reflect the colditions of pulmonary function.