双氢青蒿素与磷酸萘酚喹伍用治疗恶性疟的疗效观察

Therapeutic Effect of Dihydroartemisinin Combined with Naphthoquine Phosphate in Patients with Falciparum Malaria

目的 观察双氢青蒿素与磷酸萘酚喹配伍使用治疗恶性疟的疗效。 方法 以显微镜血检单纯恶性疟原虫阳性患者为观察对象 ,药物为双氢青蒿素 1 60mg加磷酸萘酚喹 40 0mg(成人量 ) ,一次顿服 ,服药后按时测量体温和血检原虫 ,随访 2 8d ,观察治疗效果。 结果 收治 37例恶性疟患者 ,有 1例复燃 ,治愈率为 97.3 %。平均退热时间为(1 5 .8± 8.7)h ,2 4h平均原虫下降率为 96 .7%± 2 6 .5 % ,原虫无性体转阴时间平均为 (2 7.6± 1 3 .2 )h ,药后无明显不良反应。

Objective To observe the therapeutic efficacy of dihydroartemisinin combined with naphthoquine phosphate in patients with falciparum malaria. Methods Patients with Plasmodium falciparum were selected as the subjects, treated with a single dose of dihydroarteminisinin 160 mg combined with naphthoquine phosphate 400 mg (for adults) and followed up in preselective time by blood and temperature examination for 28 days after drug administration. Results 37 patients with falciparum malaria were treated and followed up. One patient had recrudescence and the cure rate in 28 days was 97.3%(36/37). The mean fever clearance time was (15.8±8.7) hours; the mean parasite clearance time was (27.6±13.2) hours; the mean reduction parasite rate in 24 hours was 96.7%±26.5%. No apparent side effect was observed. Conclusion A combination of dihydroartemisinin and naphthoquine is effective for the treatment of patients with falciparum malaria.