p53突变蛋白在甲状腺组织中的表达及意义

Expression of p53 mutant Protein in Thyroid Carcinomas and its Signifiance

目的 :探讨抑癌基因 p5 3突变蛋白在甲状腺良恶性病变组织中表达的意义。 方法 :应用免疫组织化学方法 ,检测术前未行特殊治疗 48例甲状腺癌和 15例良性病变中 p5 3突变蛋白的表达。 结果 :p5 3突变蛋白在良性病变中无阳性表达 ,恶性肿瘤中为16/4 8(3 3 .3 % ) ,其中 ,分化性腺癌为 12 /4 3 (2 7.9% ) ,未分化癌为 4/5 (80 % )。在恶性肿瘤中 ,其表达高于良性病变 (P <0 .0 5 )。但与年龄、性别、肿瘤直径、AMES分级无明显相关。结论 :p5 3突变蛋白表达于甲状腺恶性肿瘤 ,在细胞恶性转化中发挥重要作用。

Objective:To investigate the expression of p53 mutant protein in thyroid tissue.Methods:48 patients with thyroid cancers and 15 benign diseases,without undergoing preoperative therapy,were studied for the expression of p53 mutant protein by using immunohistochemistry methods.Results:p53 mutant protein was detected in none with benign disease,while in 16/48 cases(33.3%)with thyroid cancers it was detected.Among these,12/43(27.9%) cases were of the differentiated thyroid cancer and 4/5(80.0%) the undifferentiated cancer.There is obvious difference between cancers and benign diseases,so is there,between the benign diseases and undifferentiated cancers( P <0.05).The expressions of the p53 mutant protein have no correlation with age?sex?tumor size and AMES grade.Conclusion: p53 mutant protein was expressed in maligant thyroid tissues.It plays an important role in cell transformation.