癌基因Stat3与结直肠癌临床病理特征的关系

Expression of a oncogene signal transducer and activator of transcription 3 (Stat3) and its relation to clinicopathological features of colorectal cancer

目的探讨转录信号传导子与激活子 3(Stat3)在结直肠癌中的表达情况 ,分析Stat3的表达与结直肠癌临床病理特征的关系。方法应用Westernblot检测 4 5例结直肠癌组织及其邻近正常肠粘膜中Stat3蛋白的表达。结果结直肠癌组织中Stat3蛋白表达水平明显高于正常肠粘膜(P <0 0 5 ) ,平均为正常肠粘膜的 2 4 5倍 ;Stat3表达水平与Dukes分期、分化及淋巴结转移有关 (P <0 0 5 ) ;Stat3表达水平与肿瘤大小、远处转移、年龄、性别以及是否浸润浆膜无关 (P >0 0 5 )。结论Stat3的过量表达可能在结直肠癌的发生、发展过程中起重要作用。

Objective To investigate the expression of a novel oncogene Stat3 in colorectal cancer. Methods Western blot analysis was performed on cancerous and normal colonic tissue of 45 patients with colorectal carcinoma. ResultsStat3 protein level increased in colorectal cancer compared with adjacent normal mucosa ( P <0 05), the median value was in 2 45 fold increase, it was found that overexpression of Stat3 was related to Dukes stage, differentiation and lymph node metastasis in colorectal cancer ( P <0 05). No significant differences were found between Stat3 expression and such factors as tumor size, serosa invasion and distant metastasis. Conclusions Taken together, overexpression of Stat3 may play an important role in colorectal tumorigenesis and disease progression.