胃印戒细胞癌患者的临床病理特点及术后生存

The clinicopathological features of patients with signet ring cell carcinoma of the stomach

目的研究胃印戒细胞癌患者的临床病理特点及术后生存情况。方法对 815例胃癌患者的临床病理及术后生存进行回顾性分析。结果印戒细胞癌多见于年轻女性 ,所占比例为本组胃癌的 9 9%。早期胃癌中 ,印戒细胞癌的淋巴结转移率与其他组织学类型的胃癌无差异。术后 5年生存率为 10 0 % ,优于其他类型胃癌 (82 6 % ) (P <0 0 1) ;进展期胃癌中 ,印戒细胞癌的淋巴结转移率为 4 4 4 % ,低于其他组织学类型胃癌 (74 6 % ) (P <0 0 1)。在腹膜及肝转移复发等方面与其他类型胃癌无差异。行根治性手术后 5年生存率为 5 5 3% ,高于其他组织学类型胃癌 (41 8% ) (P <0 0 5 )。结论胃印戒细胞癌与其他组织学类型的胃癌相比 ,恶性程度无差异。

ObjectiveTo study the clinicopathology and postoperative survival of patients with signet cell carcinoma of the stomach. MethodsThe clinicopathology and survival of 815 cases of gastric cancer were analyzed in this article. Results Most patients with signet ring cell carcinoma of the stomach were young female, and this cancer took up 9 9% of the total gastric cancers. In the early gastric cancer, the rate of lymph node metastasis caused by signet ring cell carcinoma was not different from that of other gastric cancer. The 5 year survival of patients with signet ring cell carcinoma was 100%, better than that of other types of gastric cancer 82 6% ( P <0 01). In the advanced gastric cancer, the rate of lymph node metastasis caused by signet ring cell carcinoma was 44 4%, which was lower than that of other type of gastric cancer (74 6%, P <0 01).The 5 year survival rate was 55 3% in patients with signet ring cell carcinoma after curative operation, which was higher than that in other types of gastric cancer (41 8%, P <0 05). ConclusionSignet ring cell carcinoma of the stomach has no difference in malignancy from other gastric cancer. Early diagnosis and active surgical treatment can improve the outcome of this kind of patients.