血栓康胶囊喷雾干燥工艺研究

Study on Process for the Spray Drying of Xueshuankang Capsules

目的:选择血栓康胶囊喷雾干燥的最佳工艺条件。方法:应用正交实验法,以每小时药粉产量为考察指标,同时兼顾药粉中的有效成分,对影响血栓康胶囊喷雾干燥过程的因素进行考察。结果:正交实验设计的三个因素中,浸膏的相对密度影响最显著,入塔风压的影响较显著。结论:最佳工艺条件:入塔风温165℃,入塔风压-1550Pa,浸膏相对密度为1.28,采用喷雾干燥的工艺生产出的血栓康胶囊,有效成分黄芪甲甙的含量明显高于湿法制粒的含量。

Objective: To select the optimum conditions for the spray drying of Xueshuankang Capsules. Methods: The process was studied by orthogonal experimental design with the average output of the extract powder as the detective marker, in the same time attention is paid to the ac- tive components. Results: The relative density of the extractive and the blast pressure are notable effect. conclusion: It is the optimum process: The wind temperature is 165℃, The blast pressure is -1550Pa, The relative density is 1.28; the content of astragaloside IV in the Xueshuankang Cap- sules manufactured by the process of the spray drying was higher than the wet methed.