甲状腺乳头状腺癌E-cadherin、CD44v6的表达

Expressions of E-cadherin and CD44v6 in papillary thyroid carcinoma

目的 :研究粘附分子E cadherin (E cd)、CD44v6在甲状腺乳头状腺癌 (PTC)中的表达及其与PTC转移的关系。方法 :应用免疫组化SP法 ,检测 70例PTC标本中E cd、CD44v6的表达。结果 :E cd、CD44v6在PTC中的阳性表达率分别为 44 .3%(31/ 70 ) ,6 7.1%(4 7/ 70 ) ,二者的表达呈明显的负相关 ;在有淋巴结转移组 ,E cd、CD44v6阳性率分别为 2 7.6 %,82 .8%,而在无淋巴结转移组分别为 5 6 .1%,5 6 .1%,两组之间差异均有统计学意义(P <0 .0 5 )。结论 :检测PTC中E cd、CD44v6的表达有助于其转移潜能的判定。

Aim: To investigate the expressions of epithelial cadherin (E-cd) and CD44v6 in the papillary thyroid carcinoma (PTC) and the correlation with metastasis. Methods: The expressions of E-cd and CD44v6 were detected by SP immunohistochemical technique in 70 specimens of PTC. Results: The positive rates of E-cd and CD44v6 were 44.3%(31/70) and 67.1%(47/70) respectively, and there was distinct negative correlation between the expressions of E-cd and CD44v6; the expressions of E-cd and CD44v6 in patients with lymph node metastasis were 27.6% and 82.8%, but in patients without metastasis were 56.1% and 56.1%. There was significant difference between the 2 groups (P< 0.01). Conclusion: Determination of E-cd and CD44v6 might be useful to predict the metastatic potential of PTC.