胃癌组织中E-钙粘附素和血管内皮生长因子的表达

Expressions of E-cadherin and VEGF in gastric cancer

目的 :探讨E 钙粘附素 (E cadherin)和血管内皮生长因子 (VEGF)表达与胃癌发生、发展的关系 ,评价E cadherin和VEGF在胃癌浸润转移及预后判断中的作用。方法 :采用SABC免疫组化染色方法 ,检测 2 0例正常胃粘膜和 6 0例胃癌手术切除标本的E cadherin和VEGF的表达情况。结果 :正常胃粘膜中E cadherin全部表达 ,胃癌组织中阳性率为 2 5 %,E cadherin与浸润深度及淋巴结转移相关 (P <0 .0 5 ) ;正常胃粘膜中VEGF均无表达 ,胃癌组织阳性率为 6 1.7%,VEGF的表达与浸润深度及淋巴结转移显著相关 (P <0 .0 1) ;E cadherin表达和VEGF表达无显著相关性 (P >0 .0 5 )。结论 :E cadherin和VEGF表达与胃癌的浸润转移密切相关 ,检测E cadherin和VEGF表达有助于胃癌转移及预后判断。

Aim: To evaluate the expressions of E-cadherin and VEGF in gastric cancer, and evaluate its value for the assessment of tumor metastatic potential and prognosis. Methods: The expressions of E-cadherin protein and VEGF protein were detected in 20 cases of normal gastric mucosa and 60 cases of gastric cancer by SABC immunohistochemistry. Results:E-cadherin expression was observed in all normal gastric mucosa, while the positive rate of E-cadherin in gastric cancer was 25%. E-cadherin expression was associated with invasive depth and lymph node metastasis(P<0.05); VEGF expression was not observed in all normal gastric mucosa, while the positive rate of VEGF in gastric cancer was 61.7%. VEGF expression was associated with invasive depth and lymph node metastasis(P<0.01). The correlation was not observed between E-cadherin expression and VEGF expression. Conclusion: Expressions of E-cadherin and VEGF are associated with invasion and metastasis in gastric cancer. Determination of E-cadherin and VEGF is helpful in predicting tumor metastatic potential and prognosis for patients with gastric cancer.