利用C_(18)固相萃取膜评价有机氯污染物的亲酯性

Evaluation of hydrophobicity for halogenated benzenes using C_(18) solid phase extraction disks

采用C18 膜模拟生物体 ,探讨了化合物在膜与水相之间分配平衡的影响因素 ,测定了卤代苯类化合物的膜 /水分配系数 .结果表明 ,随着脂溶性的增加 ,化合物分配达到平衡的时间也将增加 ;C18膜 /水分配系数的大小与水相中化合物浓度的大小和C18膜量的多少无关 ;C18膜 /水分配系数 (KSD)与正辛醇 /水分配系数 (KOW)之间有较好的一致性 .C18膜材料的使用 ,为有机污染物脂溶性的评价提供了一个新的方法 ,并且这一方法为复合污染体系因脂溶性所引起的基本毒性量化预测创造了条件 .

In this paper,factors of the partition equilibrium between C_ 18 solid phase extraction disk and water for halogenated benzenes were investigated.The C_ 18 disk/water partition coefficient was also determined.The results show that with the increase of K _ OW values,the partition equilibrium time increases.The K _ SD values is unconcerned with both the concentrations of halogenated benzenes in water and the amount of C_ 18 disks.There is a good linear relationship between K _ SD and K _ OW .The C_ 18 solid phase material is useful for evaluating the hydrophobicity of organic compounds.It is beneficial to predicting the baseline toxicity of the complex mixture.