地洛他定治疗慢性特发性荨麻疹的疗效及安全性研究

A Study on the Efficacy and Safety of Desloratadine in the Treatment of Chronic Idiopathic Urticaria

目的 观察地洛他定治疗慢性特发性荨麻疹的疗效和安全性 ,并与氯雷他定进行比较。方法 采用多中心、随机双盲、平行对照法。结果 完成治疗者共 15 8例 ,其中地洛他定组 79例。治疗后 ,患者主、客观症状观察项目平均积分于服药第 14、2 8天均有下降 ,但两组比较均无统计学意义 (P >0 .0 5 )。治疗结束时 ,地洛他定组痊愈 60例(75 .95 % ) ,总有效率 89.87% (71/79) ;氯雷他定组痊愈 5 4例 (68.3 5 % ) ,总有效率为 87.3 4% (69/79)。两组比较差异无显著性 (χ2 =0 .3 ,P >0 .0 5 )。

Objective To compare the efficacy and safety of desloratadine and loratadine of treatment for chronic idiopathic urticaria.Methods A multicentre,double blind,randomized,comparetive study was conducted.Results 158 subjects completed the trial in 4 centres,including 79 cases in desloratadin group and 79 cases in loratadine group.All symptom scores decreased significantly after treatment in both groups.The score decrease of symptoms had no significantly difference between two groups( P >0.05).At the end of the treatment,efficacy assessment based on symptom score reducing index showed that the affective rate of desloratadine and loratadine group were 89.9% and 87.3%,the clinical cure rate were 75.95% and 68.35%.No serious adverse events was recorded.Conclusion Desloratadine is safe and effective in the treatment of chronic idiopathic urticaria.