开搏通对高血压病患者血管内皮功能失调逆转作用

The Reversement of Captopril to Vascular Endothelium Function of Hypertension Patients

目的 探讨开搏通对高血压病 (EH)患者血浆内皮素 (ET)及一氧化氮 (NO)的调节作用。方法 选择 35例EH患者 ,用开搏通 12 5～ 2 5mg ,每日 3次 ,连服四周观察治疗前后血浆ET、NO水平 ,并与 32例健康者血浆ET、NO对照。结果 EH患者ET较对照组显著升高 (P <0 0 1) ,NO显著降低 (P <0 0 1)。经开搏通治疗后 ,收缩压、舒张压都显著下降 (P <0 0 1) ,ET显著下降 (P <0 0 1) ,NO显著升高 (P <0 0 1)。结论 开搏通不仅具有很好的降压作用 。

Objective To study the effect of captopril tablets on plasma endothelin(ET)and nitric oxide (NO) of the patients of hypertension. Methods The 35 selected patients of hypertension were adhibited with 12.5～25mg captopril tablets one time everyday in four weeks. ET of plasma and NO of hypertension patients were compared before treatment with those after treatment.They were also compared with 30 healthy persons too. Results ET of patients of hypertension is much higher significantly(P<0.01).NO of them is significantly lower(P<0.01).After the treatment of captopril tablets,systolic pressure and diastolic pressure lowered significantly(P<0.01),ET decreased significantly(P<0.01)and NO rose significantly(P<0.01). Conclusion Captopril tablets can not only lower blood pressure,but also ameliorate vascular endothelium function.