精神分裂症患者脑脊液中神经元特异性烯醇化酶和髓鞘碱性蛋白的研究

Study on neuron-specific enolase and myelin basic protein in cerebrospinal fluid of patients with schizophrenia.

目的 探讨精神分裂症患者是否有脑损伤。方法 对33例精神分裂症患者和9例对照组手术病人的脑脊液（CSF）中神经元特异性烯醇化酶（NSE）和髓鞘碱性蛋白（MBP）采用双抗体夹心酶联法测定。结果 病例组的NSE的含量与对照组比较有显著性差异（P<0.01）。病例组脑脊液中NSE和MBP的含量呈正相关。结论 提示精神分裂症患者有脑损伤。

Objective To study whether patients with schizophrenia have cerebral injury. Methods Neuron-specific eno-lase(NSE) and myekin basic protein (MBP) in cerebrospinal fluid (CSF) from 33 schizophrenia patients and 9 control were determined by double antibody sandwith enzyme immunassay method. Results There was significant differece in NSE contents in CSF between the schizophrenia patients and the control ( P < 0.01) . CSF-NSE positively correlated with CSF-MBP in schizophrenia patients ( P < 0.05) . Conclusions Patinent with Schizophrenia has cerebral injury.