膀胱灌注α-干扰素加丝裂霉素C预防膀胱癌术后复发

Post-operative bladder perfusion of α-IFN plus MMC to prevent recurrence of superficial bladder cancer

目的 :降低膀胱癌术后复发率 ,提高膀胱癌的治疗效果。方法 :6 3例浅表性膀胱癌术后分为两组 :①α 干扰素加丝裂霉素组 30例 ,α 干扰素 30 0万IU加丝裂霉素C 40mg加生理盐水 40ml,行膀胱灌注 ;②丝裂霉素C组 33例 ,丝裂霉素C 40mg加生理盐水 40ml,行膀胱灌注。每周 1次 ,连续 8次 ,然后 2周 1次 ,连续 8次 ,以后每个月 1次 ,总疗程 2年。结果 :随访 6～ 2 4个月 (平均 18个月 )。α 干扰素加丝裂霉素组复发 3例 ,复发率10 .0 %;丝裂霉素C组复发 13例 ,复发率 39.4%。两组比较差异有显著性意义 (P <0 .0 5 )。结论 :α 干扰素加丝裂霉素C膀胱灌注防治浅表性膀胱癌术后复发的疗效优于单用丝裂霉素C。

Purpose:To reduce the recurrence rate of the bladder cancer by the bladder installation of α-interferon plus mito-mycin C.Method:Sixty-three cases with superficial bladder cancer were divided into two groups after surgery:①Group A,30 cases treated with α-interferon plus mitomycin C, i.e. 3 million IU. α-inteferon plus C 40 mg mitomycin C plus 40 ml normal saline to be infused into the bladder,②Group B,33 cases treated with mere mitomycin C,being infused into the bladder at the dosage of 40 mg mitomycin C plus 40 ml normal saline,eight times in succession, once a week, and then eight times running,once every two weeks,and finally onc in a month, with the total course of treatment being two years.Result:Periods of follow-ups lasted 6 to 24 months (average 18 months).There were three cases (10%) in the patients treated by α-interferon plus mitomycin C and thirteen cases ( 39.4%) of bladder cancer recurrence in the patients treated with mere mitomycin C.There was remarkable difference between two groups (P< 0.05).Conclusion:The curative effect in group A with α-interferon plus mitomycin C to prevent the recurrence of superficial bladder cancer was superior to that in group B merely with mitomycin C.