摘要
目的:观察硝苯吡啶控释片联合卡维地洛对慢性肾衰高血压的降压效果及对肾功能、内皮素的影响。方法:将49例慢性肾衰高血压[血肌酐(Scr)>265μmol/L]的患者随机分为两组。A组(n=31)用硝苯吡啶控释片30～60mg/d+卡维地洛20～40mg/d;B组(n=18)硝苯吡啶控释片30～60mg/d,两组均连用8周。治疗前后测血压(BP)、血液尿素氮(BUN)、Scr、24h尿蛋白定量、内生肌酐清除率(Ccr)、血浆内皮素-1(ET-1)。结果:两组患者均可有效降低血压,A组下降幅度更明显(P<0.001),24h尿蛋白下降(P<0.01)、Scr下降(P<0.05),ET-1下降(P<0.01)。结论:硝苯吡啶控释片联合卡维地洛治疗慢性肾衰高血压可显著降低血压,改善肾功能,减少蛋白尿,安全,病人耐受性和依从性好。
To observe the therapeutic effect of adalat release controlled sheet combined with carvedilol on chronic renal failure hypertension and the effect on renal function and endothelin-1. Methods; 49 chronic renal failure hypertension patients (serum creatinine>265μmol/L) were randomly divided into two groups Group A (n = 31) adalat release conrtolled sheet 30-60mg/d combined with carvedilol 20-40mg/d were administered and in group B adalat release controlled sheet 30-60mg/d were administered, for 8 weeks groups. The blood pressure, renal function, urine protein in 24 hours,endogenous creatinine clearance rate, plasm endothelin-1 were tested. Results: After treatment the blood pressure in both groups was decreased, While adalat release controlled sheet combine with carvedilol had more effect on blood pressure than that of carvedilol (P<0.01). The urine protein in 24 hours (P<0. 01), plasma creatinine (P<0.05) , plasma endothelin-1 (P<0.01) significantly lower after treatment in group A. Conclusions: The adalat release controlled sheet combined with carvedilol could decrease the blood pressure of the chronic renal failure hypertension patients, improve the renal function, decease the urine protein and had few side effects.
