颅脑创伤后血液表观粘度的变化及iloprost对其的影响

Change of the blood apparent viscosity following tranumatic brain injury and the effects of iloprost on it

目的了解颅脑创伤后血液粘度的变化 ,观察iloprost对血液粘度的影响。方法以PBI_Ⅱ型损伤装置制成兔中度颅脑创伤 ,以iloprost治疗脑损伤(30μg·kg-1,i.v)。采集伤后1、6、24h的血样 ,用LowShear30测量表观粘度 ,同时测红细胞压积。比较各组的乘幂函数系数及红细胞压积为0.40时的表观粘度。结果颅脑创伤后1h其血液粘度即明显增加 ,伤后6h持续增加 ,伤后24h较伤后6h明显下降。与对照组相比 ,颅脑创伤后血液粘度的增加在低切下更为明显。iloprost可明显降低损伤组和对照组的血液粘度。结论颅脑创伤后血液粘度的变化可能在继发性脑损伤中起一定作用 ,iloprost可能成为治疗颅脑创伤的有效药物。

Aim The change of the blood apparent viscosity following traumatic brain injury and the effect of iloprost on it were observed.Methods The moderate brain trauma of rabbits was produced with the PBI-Ⅱ type injury device.The brain trauma was treated with iloprost (30 μg·kg-1 ,iv).The blood samples at 1? 6 and 24 h following brain trauma were collected.The apparent viscosity was measured with The Low Shear 30, and the hematocrit was measured meanwhile.The coefficient of the power function and the calculative apparent viscosity at the time when the hematocrit was 0.40, were compared. Results The blood viscosity was significantly increased at 1 h after brain trauma, and was increased continually at 6 h, but at 24 h it was distincly decresed as compared with that at 6 h.It was more increased after brain trauma at low shear than that in the control group. The blood viscosity both in the trauma and control groups was markedly decreased by the effects of iloprost. Conclusion The changes of the blood viscosity after brain trauma may play a role in the occurrence of the secondary brain damage. Iloprost may be an effective drug for treating traumatic brain injury.