氯沙坦治疗高血压病左室肥厚的临床疗效

Clinical efficacy of anti-hyperetnsive drug Iosartan in hypretensive patients with left ventricular hypertrophy

目的 研究新型的降压药物——血管紧张素受体拮抗剂氯沙坦治疗高血压病左室肥厚的临床疗效.方法21例高血压病左室肥厚患者给予氯沙坦口服20wk.治疗前后行24h动态血压监测和心脏超声检查.结果 24 h SBP、24 h DBP、dSBP、dDBP、nSBP、nDBP由治疗前(151±15)、(93±9)、(155±15)、(96±10)、(146±16)、(88±11)mmHg分别降至(132±11)、(82±8)、(137±12)、(88±9)、(120±15)、(74±9)mmHg;IVST、PWT、LV-MI由治疗前(14.2±1.5)mm、(13.9±1.45)mm、(152.1±24.2)g·m^(2-1)分别降至(12.1±1.31)mm、(12.2±1.41)mm、(130.6±23.1)g·m^(2-1),以上参数用药后均较用药前有显著下降(P＜0.0l).结论 氯沙坦能够明显降低高血压病左室肥厚患者24 h 血压,并能使其左室肥厚明显消退.

Aim The study is to observe the clinical efficacy of losartan in hypertentive patientswith left ventricular hypertrophy. Methods 21 case were given losartan for 20 wk and 24h ambulatory blood pressure monitoring and color doppler echocardiography were per-formed in the patients before and after treatment.Results The 24 h SBP, 24 h DBP,dDBP, nSBP were from (151 ± 15) 、(93 ±9)、(155 ± 15)、(96 ± 10)、(146 ± 16)、(88 ± 11)mmHg before treatment to (132 ± 11)、(82 ± 8)、(137 ± 12)、(88 ± 9)、(120 ± 9)、(120 ± 15)、(74 ± 9) mmHg after treatment respectively and the IVST, PWT and LVMI were from(14.2 ± 1 .5) mm、(13. 9 ± 1. 45) mm、(152. 1 ± 24. 2) g· m2-1 BSA before treatment to(12. 1 ± 1. 31) mm、 (12. 2 ± 1. 41) mm、(130. 6 ± 23. 1) g· m2-1 BSA after treatment re-spectively. All the parameters after treatment in the patients were significantly decreased ascompared with those before treatment (P< 0. 01 ). Conclusion Losartan can significantlylower the blood pressure and the left ventricular hypertrophy in hypertensive patients withleft ventricular hypertrophy.