注射用潘托拉唑钠抗实验性急性胃溃疡作用研究

Study of the antiulcer effect of pantoprazole

目的 研究注射用潘托拉唑钠对大鼠和小鼠急性胃溃疡动物模型的影响.方法 采用小鼠水浸应激性胃溃疡模型,大鼠幽门结扎胃溃疡模型,同时观察幽门结扎大鼠胃酸分泌情况.结果 静脉注射潘托拉唑钠5,10,20mg·kg^(-1),对小鼠水浸应激性胃溃疡具有减少溃疡发生的作用,4,8,16mg·kg^(-1)对幽门结扎大鼠的胃溃疡面积具有明显的缩小作用,两者均呈剂量依赖性.对胃酸的分泌具有较强的抑制作用,对胃蛋白酶活性也具有抑制作用.上述结果与同剂量的奥美拉唑比较作用相似.结论 注射用潘托拉唑钠对大鼠小鼠实验性急性胃溃疡具有明显的保护作用.

Aim To evaluate the effects of pantoprazole on various experimental acute ulcer inrats and mice. Methods The model of a gastric ulcer of rats or mice was caused bystree- induced ulcer and ligatel pylurus-induced ulcer. Results & Conclusions At adose of 5, 10, 20 mg· kg-1 of Pantoprazole can markedly decrease the ulcer index ofstree-induced ulcer. Pantoprazole(4, 8, 16 mg· kg -1 ) significantly decrease the areaof ligated pylorus-induced gastric ulcer. It was also found that pantoprazole caninhibit the output of basic gastric acid.